Population level impact of an imperfect prophylactic HSV-2 vaccine
نویسندگان
چکیده
Vaccine and Infectious Disease Institute, Program in Biostatistics and Biomathematics, and Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America Division of infectious diseases, Department of Biostatistics, Department of Medicine, Departments of Epidemiology, Virology Research Clinic, and Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America, Weill Cornell Medical College Qatar, Cornell University, Qatar Foundation Education City, Doha, Qatar Department of Public Health, Weill Cornell Medical College, Cornell University, New York, New York, United States of America
منابع مشابه
Effectiveness and efficiency of imperfect therapeutic HSV-2 vaccines.
BACKGROUND Efforts are currently underway to develop therapeutic vaccines for Herpes Simplex Virus type 2 (HSV-2). METHODS We use a mathematical model to predict the potential public health impact of imperfect, therapeutic HSV-2 vaccines. We evaluate vaccine effectiveness and efficiency for the general population in the United States where HSV-2 prevalence is currently 22%. We assume that the...
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Herpes simplex virus type 2 (HSV-2) is a one of the most prevalent worldwide sexually transmitted infection. HSV-2 causes recurrent genital ulcers, neonatal herpes, and also, increases the risk for HIV acquisition. Many HSV-2 vaccines have been tested in humans, but were not consistently effective. In the present work we tried to produce a model vaccine for HSV-2 formulated in different formula...
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Genital Herpes, which is caused by Herpes Simplex Virus-1 or -2 (HSV-1, -2, predominantly HSV-2) is a sexually transmitted infection (STI) that causes a chronic latent infection with outbreak episodes linked to transmission. Antiviral therapies are effective in reducing viral shedding during these episodes, but are ineffective as a whole since many outbreaks are asymptomatic or have mild sympto...
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Herpes simplex virus 2 (HSV-2) infects the genital mucosa and establishes a life-long infection in sensory ganglia. After primary infection HSV-2 may reactivate causing recurrent genital ulcerations. HSV-2 infection is prevalent, and globally more than 400 million individuals are infected. As clinical trials have failed to show protection against HSV-2 infection, new vaccine candidates are warr...
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تاریخ انتشار 2009